Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• multifunctional PEGylated magnetic nanoparticles coated with polydopamine (PDA) exhibit strong near-infrared absorption because of the PDA layer and have the ability to deliver drugs under a magnetic field owing to their superparamagnetism [51]. During the drug loading studies, the anticancer drug vinorelbine was

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• ]. A biomimetic particle model using PLGA NPs as a carrier for the anticancer drug doxorubicin (Dox) encapsulated by the HepG2 liver cancer cell membrane was designed for the treatment of HCC [31]. The HepG2 cell membrane-encapsulated NPs exhibited superior antitumor effects compared to bare NPs and

• targeting and hyperthermia [56]. In a therapeutic strategy for HCC, hepatoma cell membranes and macrophage membranes were hybridized to obtain the advantages of different cell membranes [78]. When nanocarriers with photothermal conversion ability were used to carry the anticancer drug sorafenib, efficient

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• expression has not only improved current therapeutic plans for cancer patients but has had an impact on the design approaches of the nanotools for cancer imaging and anticancer drug delivery. In recent years, new platforms to enhance the low tumor targeting capacity of nanomedicines using biomimetic

• of molecularly targeted drugs, chemotherapeutic agents, and siRNA. Historically, the most promising first-generation, passive targeting, stealth polymer NPs for anticancer drug/gene delivery are hydrophobic core–hydrophilic shell NPs including (i) self-assembled kinetically stable amphiphilic block

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• very stiff. Upon photoirradiation, however, the crosslinkings for the gel formation are broken almost completely, releasing the encapsulated drugs (e.g., DOX as anticancer drug). 2.3 Upconversion nanoparticles to release drugs by near-infrared light As an external stimulus for DDSs, near-infrared (NIR

• recent topics on medical applications of CyD 6.1 Chemical modification of CyD for precise targeting to predetermined cells A multicharged nanoassembly was constructed from β-CyD bearing seven hexylimidazolium units, adamantane-grafted hyaluronic acid, and chlorambucil (an anticancer drug) [90]. In cancer

• efficacy of chlorambucil was greatly increased since it remained in the cell for a long time. Furthermore, an anticancer drug and a resistance-suppressing gene were simultaneously delivered for cooperation [91]. For delayed drug release, anionic β-CyD polymers bearing carboxylate residues are useful [92

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• drug delivery system loaded with docetaxel (DCX) as an anticancer drug, using poly(lactic-co-glycolic acid) (PLGA) as nanoparticle material, and modified with chitosan (CS) to gain mucoadhesive properties. In this context, an innovative nanoparticle formulation that can protect orally administered DCX

• studies on the Caco-2 cell line, the CS/DCX-PLGA formulation increased permeability by 383% compared to free DCX (p < 0.05). In the light of all results, CS/DCX-PLGA NPs can offer a promising and innovative approach as an oral anticancer drug-loaded nanoformulation for intestinal tumors. Keywords

Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis

• Camila Felix Vecchi,
• Rafaela Said dos Santos,
• Jéssica Bassi da Silva and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42

• extracts. PRP exhibits important pharmacological activity, already proven in several studies, in addition to being a biologically safe compound [17][18][19][20][21]. This natural drug is also widely used as antimicrobial agent, immune system strengthener, and anticancer drug in the form of its ethanolic or

Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

• Xiaoteng Liang,
• Shuai Liu,
• Xiuchao Wang,
• Dan Xia and
• Qiang Li

Beilstein J. Nanotechnol. 2021, 12, 1372–1379, doi:10.3762/bjnano.12.101

• aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells. Keywords: anticancer drug; atomic force microscopy; nanomechanical

• ultrastructure of living cells [15][16], cell membranes, membrane proteins [17][18] and DNA [19], and through recording single molecular force spectra [20][21]. However, the morphology and the nanoscale mechanical properties of malignant pancreatic cancer cells (PCCs) under anticancer drug treatment have not

• concentrations, which is believed to enable an estimation of the internal structural changes of MIA PaCa-2 cells treated with DOX. This technique could be utilized to evaluate the anticancer drug effect on PCCs in patients treated with anticancer drugs even when the cell morphology does not change significantly

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• cytotoxicity of these nanocarriers for potential anticancer drug delivery systems. Results and Discussion Physical characterizations The X-ray diffraction (XRD) data of all samples was analyzed using Rietveld refinement techniques in the Fullprof Suit program. The data was refined according to their space

• ) NPs for in vitro anticancer drug delivery. All nanocarriers showed significantly increased (p < 0.005) drug release at an acidic pH value (pH 5.5) compared to that at a physiological pH value (pH 7.4), indicating their specificity towards cancer cells. In vitro cytotoxicity analysis indicated

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• alternatives using NDDSs [1]. Literature data points to combinatorial therapy, coadministration, and codelivery of agents by nanomedicines as a successful approach to bypass signaling inhibition, combat anticancer drug resistance, and increase the efficacy of the clinical treatment. Further advances in

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• limited due to several unwanted characteristics of poor solubility, broad bioavailability range, narrow therapeutic index, rapid elimination from systemic circulation, unselective site of action after oral/intravenous administration, and cytotoxic effects on normal tissues [6]. The anticancer drug

• -suspended in 2 mL deionized water and stored at 4 °C. Doxorubicin-loaded PSS-GNRs The anticancer drug DOX was loaded onto the surface of PSS-GNRs by a previously reported simple stirring method with slight modifications [30]. PSS-GNRs (40 µg/mL, 2 mL) were added to an aqueous solution of DOX at a final

Examination of the relationship between viscoelastic properties and the invasion of ovarian cancer cells by atomic force microscopy

• Mengdan Chen,
• Jinshu Zeng,
• Weiwei Ruan,
• Zhenghong Zhang,
• Yuhua Wang,
• Shusen Xie,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2020, 11, 568–582, doi:10.3762/bjnano.11.45

• with cancer invasion after anticancer drug treatment [24][25]. Echinomycin serves as a potential therapeutic agent through the induction of cell apoptosis, which is typically used in the treatment of epithelial cancers, including ovary, breast and prostate cancers [26][27][28][29]. Inhibitory

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• efficient carriers for controlled release. The later work on capsule/lipid systems incorporated with neoglycolipid or folate-linked lipid showed high affinity to lectin (concanavalin A) and breast cancer cells (MCF-7) [109]. The efficient delivery of the daunorubicin hydrochloride (DNR) anticancer drug to

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• chlorin-e6, an azobenzene group that can be cleaved at very low oxygen concentrations links the hydrophobic and the hydrophilic block. Upon irradiation and depletion of oxygen due to the PDT activity of chlorin-e6, the block copolymer nanovector disassembled and the anticancer drug, doxorubicin, was

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• the ECL quenching via formation of hydrogen peroxide. Kim and co-workers developed an innovative approach of intercalation of the anticancer drug doxorubicin within the DNA tetrahedron that showed improved therapeutic efficacy in drug-resistant breast cancer cells [70]. The doxorubicin-encapsulated

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• represent 77%, 17% and 3% of the content of the dried extract from curcuma root, respectively [30][31]. CUR has shown anti-inflammatory, antirheumatic and antioxidant activities and it has been used in hepatic and other chronic diseases including diabetes [32]. Recently, the activity of CUR as an anticancer

• drug has been evidenced and shown to act on a variety of molecular targets that regulate the proliferation and apoptosis, decrease the expression of NF-κB and increase insulin-like growth factor-binding protein 5 (IGFBP-5) and cytochrome P450, family 1, member A1 (CYP1A1) [32][33][34]. Moreover, CUR

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• ). In vitro anticancer studies Cisplatin is a well-known efficient anticancer drug that binds to DNA blocking cell division. As with many anticancer drugs, cisplatin has off-target toxicity, mainly in the kidneys, liver, heart, nerves, and ears. In addition, most patients develop chemoresistance to

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery. Keywords: cytotoxicity; doxorubicin; magnetic; nanoparticles; poly[N-(2-hydroxypropyl)methacrylamide]; Introduction Severe

• activity of Dox-conjugated poly[N-(2-hydroxypropyl)methacrylamide-co-2-(N-methylmethacrylamido)acetate] [P(HPMA-MMAA)]-coated magnetic γ-Fe2O3 particles [γ-Fe2O3@P(HPMA-MMAA)-Dox] as a prospective vehicle for the transport of anticancer drug into cells. To the best of our knowledge, polymers based on

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• alternative to the antimitotic drug, which causes severe side effects when administrated alone. Keywords: 5-FU; anticancer drug delivery; apoptosis; calcium phosphate nanoparticles; cell cycle; nanomedicine; Introduction Malignant neoplasms are reported as the second most common cause of mortality around

• nanoparticles in biomedical applications is extended to tissue engineering, gene/siRNA delivery, anticancer drug delivery, protein and antigen delivery, vaccine delivery, insulin as well as imaging probe or contrasting agent delivery for bio-imaging. 5-Fluorouracil (5-FU), a well-known anticancer agent

• the synthesis of CaP@5-FU NPs. Results and Discussion Synthesis of CaP@5-FU NPs The microemulsion reverse micelle method [12] was adopted for the effective synthesis of calcium phosphate nanoparticles. Furthermore, in situ loading of the anticancer drug (5-FU) during the synthesis yielded efficient

Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications

• Arūnas Jagminas,
• Agnė Mikalauskaitė,
• Vitalijus Karabanovas and
• Jūrate Vaičiūnienė

Beilstein J. Nanotechnol. 2017, 8, 1734–1741, doi:10.3762/bjnano.8.174

• conjugated with targeting and chemotherapy agents, such as cancer stem cell-related antibodies and the anticancer drug doxorubicin, for early detection and improved treatment. In order to verify our findings, high-resolution transmission electron microscopy (HRTEM), atomic force microscopy (AFM), FTIR

A nanocomplex of C₆₀ fullerene with cisplatin: design, characterization and toxicity

• Svitlana Prylutska,
• Svitlana Politenkova,
• Kateryna Afanasieva,
• Volodymyr Korolovych,
• Kateryna Bogutska,
• Andriy Sivolob,
• Larysa Skivka,
• Maxim Evstigneev,
• Viktor Kostjukov,
• Yuriy Prylutskyy and
• Uwe Ritter

Beilstein J. Nanotechnol. 2017, 8, 1494–1501, doi:10.3762/bjnano.8.149

• are transformed into lymphoblast) a large set of genes are activated to allow the entry of cells in the G1 phase of the cell cycle [51]. Probably, such transformation that never occurs in vivo in lymphocytes under normal conditions, leads to an increase in the cells' sensitivity to the anticancer drug

• evaluate the level of blast transformation (the fraction of lymphoblasts). Incubation of lymphocytes and lymphoblasts The cell suspension in RPMI 1640 medium (cell concentration in the range of 1 × 105 to 5 × 105 cells per mL) was incubated in the presence of either C60 fullerene (0.1 mg/mL), anticancer

• drug Сіs (0.01, 0.1 or 0.15 mg/mL) or the complex of C60 fullerene with Cis (Cis concentration was 0.1 or 0.15 mg/L, the C60 fullerene to Cis molar ratio was equal to 1:2.4) for 1.5 h at 37 °C, washed once in 0.15 M NaCl, and then used for the comet assay. Five to seven independent repeats of the

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• , Spain Department of Organic Chemistry, University of Sevilla, C/ Prof García Gonzalez 1, Sevilla, 41012, Spain Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Turkey 10.3762/bjnano.8.145 Abstract Background: Paclitaxel is a potent anticancer drug that

• cells. The amphiphilic, cationic PC βCDC6 derivative was used as the anticancer drug carrier delivery system for PCX for the first time in this study. There are various studies in which this derivative is used as a gene transfer delivery system; however, there is only example where this derivative was

• used as a drug delivery system. This was a study regarding the non-polar anxiolytic drug diapezam realized by Mendez-Ardoy et al. [22]. Our goal is to evaluate the potential of the polycationic CD nanoparticles as an anticancer drug delivery system. In fact, these polycationic CDs were evaluated for

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• that active targeted PEG/PCL nanoparticles enhanced tumor penetration [22]. Besides that, Ungaro et al. obtained docetaxel-loaded core–shell PEO/PCL nanoassemblies for passive targeting of the anticancer drug to cancer cells. Their results showed that docetaxel-loaded PEO/PCL nanoparticles were more

• when compared with non-coated nanoparticles. Conclusion In this study, the anticancer drug DOC, encapsulated in anionic and cationic polymeric nanoparticles and administered in a bioadhesive film formulation, was successfully developed to apply the chemotherapeutic drug directly to the action site

• from Sigma-Aldrich, USA. Chitosan (Protasan® G 113, MW < 200 kDa, deacetylation degree 75–90%) was purchased from FMC Biopolymers, Norway. HpC (Klucel™ hydroxypropylcellulose) was purchased from Ashland, USA. The model anticancer drug, docetaxel (purity 97%), was purchased from Fluka, Switzerland

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• , College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, 310018, China 10.3762/bjnano.7.178 Abstract In addition to its well-known abortifacient effect, mifepristone (MIF) has been used as an anticancer drug for various cancers in many studies with an in-depth understanding of the

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• Dorota Matyszewska Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02089 Warsaw, Poland 10.3762/bjnano.7.46 Abstract In this work the interactions of an anticancer drug daunorubicin (DNR) with model thiolipid layers composed of 1,2

• agent as the drug in the free form but in the same time they do not influence the organization and properties of the membranes to such extent as the free drug. Conclusion Interactions of anticancer drug daunorubicin with model thiolipid membranes were investigated using Langmuir technique and